Variant Ciz1 is a circulating biomarker for early-stage lung cancer

There is an unmet need for circulating biomarkers that can detect early-stage lung cancer. Here we show that a variant form of the nuclear matrix-associated DNA replication factor Ciz1 is present in 34/35 lung tumors but not in adjacent tissue, giving rise to stable protein quantifiable by Western b...

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Autori principali: Higgins, Gillian, Roper, Katherine M., Watson, Irene J., Blackhall, Fiona H., Rom, William N., Pass, Harvey I., Ainscough, Justin F. X., Coverley, Dawn
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494940/
https://ncbi.nlm.nih.gov/pubmed/23074256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210107109
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