Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

Synaptic degeneration, including impairment of synaptic plasticity and loss of synapses, is an important feature of Alzheimer disease pathogenesis. Increasing evidence suggests that these degenerative synaptic changes are associated with an accumulation of soluble oligomeric assemblies of amyloid β...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Zhao, Wei-Qin, Santini, Francesca, Breese, Robert, Ross, Dave, Zhang, Xiaohua Douglas, Stone, David J., Ferrer, Marc, Townsend, Matthew, Wolfe, Abigail L., Seager, Matthew A., Kinney, Gene G., Shughrue, Paul J., Ray, William J.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2010
الموضوعات:
Neurobiology
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844209/
https://ncbi.nlm.nih.gov/pubmed/20032460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057182
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