Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

Synaptic degeneration, including impairment of synaptic plasticity and loss of synapses, is an important feature of Alzheimer disease pathogenesis. Increasing evidence suggests that these degenerative synaptic changes are associated with an accumulation of soluble oligomeric assemblies of amyloid β...

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Main Authors: Zhao, Wei-Qin, Santini, Francesca, Breese, Robert, Ross, Dave, Zhang, Xiaohua Douglas, Stone, David J., Ferrer, Marc, Townsend, Matthew, Wolfe, Abigail L., Seager, Matthew A., Kinney, Gene G., Shughrue, Paul J., Ray, William J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844209/
https://ncbi.nlm.nih.gov/pubmed/20032460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057182
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