Role of Arginine Guanidinium Moiety in Nitric-oxide Synthase Mechanism of Oxygen Activation

Nitric-oxide synthases (NOS) are highly regulated heme-thiolate enzymes that catalyze two oxidation reactions that sequentially convert the substrate l-Arg first to N(ω)-hydroxyl-l-arginine and then to l-citrulline and nitric oxide. Despite numerous investigations, the detailed molecular mechanism o...

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Bibliographic Details
Main Authors: Giroud, Claire, Moreau, Magali, Mattioli, Tony A., Balland, Véronique, Boucher, Jean-Luc, Xu-Li, Yun, Stuehr, Dennis J., Santolini, Jérôme
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844172/
https://ncbi.nlm.nih.gov/pubmed/19951943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038240
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