Mycobacterium tuberculosis cAMP Receptor Protein (Rv3676) Differs from the Escherichia coli Paradigm in Its cAMP Binding and DNA Binding Properties and Transcription Activation Properties

The pathogen Mycobacterium tuberculosis produces a burst of cAMP upon infection of macrophages. Bacterial cyclic AMP receptor proteins (CRP) are transcription factors that respond to cAMP by binding at target promoters when cAMP concentrations increase. Rv3676 (CRP(Mt)) is a CRP family protein that...

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Bibliografiset tiedot
Päätekijät: Stapleton, Melanie, Haq, Ihtshamul, Hunt, Debbie M., Arnvig, Kristine B., Artymiuk, Peter J., Buxton, Roger S., Green, Jeffrey
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2010
Aiheet:
Gene Regulation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844151/
https://ncbi.nlm.nih.gov/pubmed/20028978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047720
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