Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response()

The Rv0805 gene in Mycobacterium tuberculosis encodes a metallophosphoesterase which shows cAMP-hydrolytic activity. Overexpression of Rv0805 has been used as a tool to lower intracellular cAMP levels and thereby elucidate the roles of cAMP in mycobacteria. Here we show that levels of cAMP in M. tub...

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Bibliografiske detaljer
Main Authors: Matange, Nishad, Hunt, Debbie M., Buxton, Roger S., Visweswariah, Sandhya S.
Format: Artigo
Sprog:Inglês
Udgivet: Churchill Livingstone 2013
Fag:
Molecular Aspects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776917/
https://ncbi.nlm.nih.gov/pubmed/23835087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2013.05.004
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