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Discovery of 4-(4-(2-((5-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)-ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: In vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson’s Disease
The role of iron in the pathogenesis of Parkinson’s disease (PD) has been implicated strongly due to generation of oxidative stress leading to dopamine cell death. In our overall goal to develop bifunctional/multifunctional drugs, we designed dopamine D2/D3 agonist molecules with a capacity to bind...
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Main Authors: | , , , |
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Format: | Artigo |
Language: | Inglês |
Published: |
2010
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844127/ https://ncbi.nlm.nih.gov/pubmed/20146482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901618d |
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