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Role for ADAP in shear flow–induced platelet mechanotransduction

Binding of platelets to fibrinogen via integrin αIIbβ3 stimulates cytoskeletal reorganization and spreading. These responses depend on tyrosine phosphorylation of multiple proteins by Src family members and Syk. Among Src substrates in platelets is adhesion- and degranulation-promoting adapter prote...

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Hlavní autoři: Kasirer-Friede, Ana, Ruggeri, Zaverio M., Shattil, Sanford J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844019/
https://ncbi.nlm.nih.gov/pubmed/19996090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-238238
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