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Role for ADAP in shear flow–induced platelet mechanotransduction
Binding of platelets to fibrinogen via integrin αIIbβ3 stimulates cytoskeletal reorganization and spreading. These responses depend on tyrosine phosphorylation of multiple proteins by Src family members and Syk. Among Src substrates in platelets is adhesion- and degranulation-promoting adapter prote...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Hematology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844019/ https://ncbi.nlm.nih.gov/pubmed/19996090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-238238 |
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