ADAP is required for normal αIIbβ3 activation by VWF/GP Ib-IX-V and other agonists

Interaction between von Willebrand factor (VWF) and platelet GP Ib-IX-V is required for hemostasis, in part because intracellular signals from VWF/GP Ib-IX-V activate the ligand-binding function of integrin αIIbβ3. Because they also induce tyrosine phosphorylation of the ADAP adapter, we investigate...

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Detalhes bibliográficos
Main Authors: Kasirer-Friede, Ana, Moran, Barry, Nagrampa-Orje, Jennifer, Swanson, Ken, Ruggeri, Zaverio M., Schraven, Burkhart, Neel, Benjamin G., Koretzky, Gary, Shattil, Sanford J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785130/
https://ncbi.nlm.nih.gov/pubmed/17003372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-022301
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