Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells

Chronic myeloid leukemia (CML) is treated effectively with tyrosine kinase inhibitors (TKIs); however, 2 key problems remain—the insensitivity of CML stem and progenitor cells to TKIs and the emergence of TKI-resistant BCR-ABL mutations. BCR-ABL activity is associated with increased proteasome activ...

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Hauptverfasser: Heaney, Nicholas B., Pellicano, Francesca, Zhang, Bin, Crawford, Lisa, Chu, Su, Kazmi, Syed M. A., Allan, Elaine K., Jorgensen, Heather G., Irvine, Alexandra E., Bhatia, Ravi, Holyoake, Tessa L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844011/
https://ncbi.nlm.nih.gov/pubmed/20068223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-164582
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