Sequential treatment of CD34(+) cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells

Because primary myelofibrosis (PMF) originates at the level of the pluripotent hematopoietic stem cell (HSC), we examined the effects of various therapeutic agents on the in vitro and in vivo behavior of PMF CD34(+) cells. Treatment of PMF CD34(+) cells with chromatin-modifying agents (CMAs) but not...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Xiaoli, Zhang, Wei, Tripodi, Joseph, Lu, Min, Xu, Mingjiang, Najfeld, Vesna, Li, Yan, Hoffman, Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031385/
https://ncbi.nlm.nih.gov/pubmed/20858855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-269696
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