Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M(1)) anatgonists

This Letter describes the synthesis and SAR, developed through an iterative analog library approach, of a novel series of selective M(1) mAChR antagonists, based on an N-(4-(4-alkylpiperazin-1-yl)phenyl)benzamide scaffold for the potential treatment of Parkinson's disease, dystonia and other mo...

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Bibliographische Detailangaben
Hauptverfasser: Miller, Nicole R., Daniels, R. Nathan, Lee, David, Conn, P. Jeffrey, Lindsley, Craig W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843780/
https://ncbi.nlm.nih.gov/pubmed/20202841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.02.041
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