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Novel EphB4 Monoclonal Antibodies Modulate Angiogenesis and Inhibit Tumor Growth
EphB4 receptor tyrosine kinase and its cognate ligand EphrinB2 regulate induction and maturation of newly forming vessels. Inhibition of their interaction arrests angiogenesis, vessel maturation, and pericyte recruitment. In addition, EphB4 is expressed in the vast majority of epithelial cancers and...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2843490/ https://ncbi.nlm.nih.gov/pubmed/20133814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090755 |
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