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Novel EphB4 Monoclonal Antibodies Modulate Angiogenesis and Inhibit Tumor Growth
EphB4 receptor tyrosine kinase and its cognate ligand EphrinB2 regulate induction and maturation of newly forming vessels. Inhibition of their interaction arrests angiogenesis, vessel maturation, and pericyte recruitment. In addition, EphB4 is expressed in the vast majority of epithelial cancers and...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Investigative Pathology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2843490/ https://ncbi.nlm.nih.gov/pubmed/20133814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090755 |
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