Novel EphB4 Monoclonal Antibodies Modulate Angiogenesis and Inhibit Tumor Growth

EphB4 receptor tyrosine kinase and its cognate ligand EphrinB2 regulate induction and maturation of newly forming vessels. Inhibition of their interaction arrests angiogenesis, vessel maturation, and pericyte recruitment. In addition, EphB4 is expressed in the vast majority of epithelial cancers and...

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Main Authors: Krasnoperov, Valery, Kumar, S. Ram, Ley, Eric, Li, Xiuqing, Scehnet, Jeffrey, Liu, Ren, Zozulya, Sergey, Gill, Parkash S.
格式: Artigo
語言:Inglês
出版: American Society for Investigative Pathology 2010
主題:
Regular Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843490/
https://ncbi.nlm.nih.gov/pubmed/20133814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090755
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