Novel EphB4 Monoclonal Antibodies Modulate Angiogenesis and Inhibit Tumor Growth

EphB4 receptor tyrosine kinase and its cognate ligand EphrinB2 regulate induction and maturation of newly forming vessels. Inhibition of their interaction arrests angiogenesis, vessel maturation, and pericyte recruitment. In addition, EphB4 is expressed in the vast majority of epithelial cancers and...

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Bibliografiske detaljer
Main Authors: Krasnoperov, Valery, Kumar, S. Ram, Ley, Eric, Li, Xiuqing, Scehnet, Jeffrey, Liu, Ren, Zozulya, Sergey, Gill, Parkash S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843490/
https://ncbi.nlm.nih.gov/pubmed/20133814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090755
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