The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth

The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis. The soluble monomeric derivative of the extracellular domain of EphB4 (sEphB4) was designed as an antagonist of EphB4/EphrinB2 signaling. sEphB4 blocks activation of EphB4 and...

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Bibliografiske detaljer
Main Authors: Kertesz, Nathalie, Krasnoperov, Valery, Reddy, Ramachandra, Leshanski, Lucy, Kumar, S. Ram, Zozulya, Sergey, Gill, Parkash S.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2006
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895726/
https://ncbi.nlm.nih.gov/pubmed/16322467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1655
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