Hypoxic Regulation of Nucleus Pulposus Cell Survival : From Niche to Notch

This minireview examines the role of hypoxia, and hypoxia inducible factors (HIF-1 and HIF-2), in regulating the metabolism, function, and fate of cells of the nucleus pulposus in the intervertebral disk. We focus on the mechanisms by which both these hypoxia-sensitive transcription factors influenc...

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Bibliographic Details
Main Authors: Risbud, Makarand V., Schipani, Ernestina, Shapiro, Irving M.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2010
Subjects:
Mini-Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843446/
https://ncbi.nlm.nih.gov/pubmed/20133815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090734
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