Hypoxic regulation of mitochondrial metabolism and mitophagy in nucleus pulposus cells is dependent on HIF-1α -BNIP3 axis

Nucleus pulposus (NP) cells reside in an avascular and hypoxic microenvironment of intervertebral discs and are predominantly glycolytic due to robust HIF-1 activity. It is generally thought that NP cells contain few functional mitochondria compared to cells that rely on oxidative metabolism. Conseq...

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Pubblicato in:J Bone Miner Res
Autori principali: Madhu, Vedavathi, Boneski, Paige K, Silagi, Elizabeth, Qiu, Yunping, Kurland, Irwin, Guntur, Anyonya R, Shapiro, Irving M, Risbud, Makarand V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778522/
https://ncbi.nlm.nih.gov/pubmed/32251541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.4019
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