Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

Activation of the inflammasome generates the pro-inflammatory cytokines interleukin-1β and -18, which are important mediators of inflammation. Abnormal activation of the inflammasome leads to many inflammatory diseases, including gout, silicosis, neurodegeneration, and genetically inherited periodic...

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Detalles Bibliográficos
Autores principales: Juliana, Christine, Fernandes-Alnemri, Teresa, Wu, Jianghong, Datta, Pinaki, Solorzano, Leobaldo, Yu, Je-Wook, Meng, Rong, Quong, Andrew A., Latz, Eicke, Scott, Charles P., Alnemri, Emad S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843228/
https://ncbi.nlm.nih.gov/pubmed/20093358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082305
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