The Angelman Syndrome-associated ubiquitin ligase Ube3A regulates synapse development by ubiquitinating Arc

Angelman Syndrome is a debilitating neurological disorder caused by mutation of the E3 ubiquitin ligase Ube3A, a gene whose mutation has also recently been associated with autism spectrum disorders (ASDs). The function of Ube3A during nervous system development, and how Ube3A mutations give rise to...

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Autori principali: Greer, Paul L., Hanayama, Rikinari, Bloodgood, Brenda L., Mardinly, Alan R., Lipton, David M., Flavell, Steven W., Kim, Tae-Kyung, Griffith, Eric C., Waldon, Zachary, Maehr, Rene, Ploegh, Hidde L., Chowdhury, Shoaib, Worley, Paul F., Steen, Judith, Greenberg, Michael E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843143/
https://ncbi.nlm.nih.gov/pubmed/20211139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.01.026
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