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Determination of primary structure and microheterogeneity of a β-amyloid plaque-specific antibody using high performance LC- tandem mass spectrometry

Using the “bottom-up” approach and liquid chromatography in combination with mass spectrometry, the primary structure and sequence microheterogeneity of a plaque-specific anti-β-amyloid (1–17) monoclonal antibody (clone 6E10) was characterized. This study describes the extent of structural informati...

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Hlavní autoři: Perdivara, Irina, Deterding, Leesa, Moise, Adrian, Tomer, Kenneth B., Przybylski, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842979/
https://ncbi.nlm.nih.gov/pubmed/18369607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-008-1941-z
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