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Inhibition of PI-3K restores nuclear p27(Kip1) expression in a mouse model of K-ras driven lung cancer
Reduced expression of the CDK inhibitor p27(Kip1) (p27) in human lung cancer correlates with tumour aggressiveness and poor prognosis. However, the regulation of p27 expression and the role of p27 during lung cancer are poorly understood. Urethane-induced lung tumours in mice frequently harbor mutat...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2842079/ https://ncbi.nlm.nih.gov/pubmed/19648963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.226 |
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