Complex Regulation of the Cyclin-Dependent Kinase Inhibitor p27(kip1) in Thyroid Cancer Cells by the PI3K/AKT Pathway: Regulation of p27(kip1) Expression and Localization

Functional inactivation of the tumor suppressor p27(kip1) in human cancer occurs either through loss of expression or through phosphorylation-dependent cytoplasmic sequestration. Here we demonstrate that dysregulation of the PI3K/AKT pathway is important in thyroid carcinogenesis and that p27(kip1)...

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Detalhes bibliográficos
Main Authors: Motti, Maria Letizia, Califano, Daniela, Troncone, Giancarlo, De Marco, Carmela, Migliaccio, Ilenia, Palmieri, Emiliano, Pezzullo, Luciano, Palombini, Lucio, Fusco, Alfredo, Viglietto, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2005
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602368/
https://ncbi.nlm.nih.gov/pubmed/15743786
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