Complex Regulation of the Cyclin-Dependent Kinase Inhibitor p27(kip1) in Thyroid Cancer Cells by the PI3K/AKT Pathway: Regulation of p27(kip1) Expression and Localization

Functional inactivation of the tumor suppressor p27(kip1) in human cancer occurs either through loss of expression or through phosphorylation-dependent cytoplasmic sequestration. Here we demonstrate that dysregulation of the PI3K/AKT pathway is important in thyroid carcinogenesis and that p27(kip1)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Motti, Maria Letizia, Califano, Daniela, Troncone, Giancarlo, De Marco, Carmela, Migliaccio, Ilenia, Palmieri, Emiliano, Pezzullo, Luciano, Palombini, Lucio, Fusco, Alfredo, Viglietto, Giuseppe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Investigative Pathology 2005
Pynciau:
Original Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602368/
https://ncbi.nlm.nih.gov/pubmed/15743786
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg