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Leptin therapy in insulin-deficient type I diabetes
In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined with low-dose insulin reverses the catabolic state through suppression of hyperglucagonemia. Additionally, it mimics the anabolic actions of insulin monotherapy and normalizes hemoglobin A1c with far less g...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841945/ https://ncbi.nlm.nih.gov/pubmed/20194735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909422107 |
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