Loss of high-frequency glucose-induced Ca(2+) oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5(−/−) mice

Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (V(m)) and the cytosolic calcium level ([Ca(2+)](cyt)). We propose that TRPM5, a Ca(2+)-activated monovalent cation channel, is a...

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Hlavní autoři: Colsoul, Barbara, Schraenen, Anica, Lemaire, Katleen, Quintens, Roel, Van Lommel, Leentje, Segal, Andrei, Owsianik, Grzegorz, Talavera, Karel, Voets, Thomas, Margolskee, Robert F., Kokrashvili, Zaza, Gilon, Patrick, Nilius, Bernd, Schuit, Frans C., Vennekens, Rudi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841940/
https://ncbi.nlm.nih.gov/pubmed/20194741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913107107
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