Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

Measurements of nucleoside triphosphate levels in Saccharomyces cerevisiae reveal that the four rNTPs are in 36- to 190-fold molar excess over their corresponding dNTPs. During DNA synthesis in vitro using the physiological nucleoside triphosphate concentrations, yeast DNA polymerase ε, which is imp...

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Main Authors: Nick McElhinny, Stephanie A., Watts, Brian E., Kumar, Dinesh, Watt, Danielle L., Lundström, Else-Britt, Burgers, Peter M. J., Johansson, Erik, Chabes, Andrei, Kunkel, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841928/
https://ncbi.nlm.nih.gov/pubmed/20194773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914857107
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