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Allosteric modulation of Ras positions Q61 for a direct role in catalysis
Ras and its effector Raf are key mediators of the Ras/Raf/MEK/ERK signal transduction pathway. Mutants of residue Q61 impair the GTPase activity of Ras and are found prominently in human cancers. Yet the mechanism through which Q61 contributes to catalysis has been elusive. It is thought to position...
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| Main Authors: | , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
National Academy of Sciences
2010
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841912/ https://ncbi.nlm.nih.gov/pubmed/20194776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912226107 |
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