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Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular processes including protein degradation, mitochondrial homeostasis, and autophagy; however, its precise role in pathogenes...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841909/ https://ncbi.nlm.nih.gov/pubmed/20194754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913485107 |
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