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Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity
The Gibbs free energy difference between native and unfolded states (“stability”) is one of the fundamental characteristics of a protein. By exploiting the thermodynamic linkage between ligand binding and stability, interactions of a protein with small molecules, nucleic acids, or other proteins can...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841886/ https://ncbi.nlm.nih.gov/pubmed/20194783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910421107 |
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