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The prognostic IDH1(R132) mutation is associated with reduced NADP(+)-dependent IDH activity in glioblastoma
Somatic mutations in the isocitrate dehydrogenase 1 gene (IDH1) occur at high frequency in gliomas and seem to be a prognostic factor for survival in glioblastoma patients. In our set of 98 glioblastoma patients, IDH1 (R132) mutations were associated with improved survival of 1 year on average, afte...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Springer-Verlag
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841753/ https://ncbi.nlm.nih.gov/pubmed/20127344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-010-0645-6 |
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