Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display

To demonstrate the utility of phage display in generating highly specific antibodies, affinity selections were conducted on 20 related Src Homology 2 (SH2) domains (ABL1, ABL2, BTK, BCAR3, CRK, FYN, GRB2, GRAP2, LYN, LCK, NCK1, PTPN11 C, PIK3R1 C, PLCγ1 C, RASA1 C, SHC1, SH2D1A, SYK N, VAV1 and the...

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Bibliografiska uppgifter
Huvudupphovsmän: Pershad, K., Pavlovic, J.D., Gräslund, S., Nilsson, P., Colwill, K., Karatt-Vellatt, A., Schofield, D.J., Dyson, M.R., Pawson, T., Kay, B.K., McCafferty, J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841545/
https://ncbi.nlm.nih.gov/pubmed/20164216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzq003
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