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The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness

TCR interactions with cognate peptide-MHC (pepMHC) ligands are generally low affinity. This feature, together with the requirement for CD8/CD4 participation, has made it difficult to dissect relationships between TCR-binding parameters and T cell activation. Interpretations are further complicated w...

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Bibliografiske detaljer
Main Authors: Chervin, Adam S., Stone, Jennifer D., Holler, Phillip D., Bai, Ailin, Chen, Jianzhu, Eisen, Herman N., Kranz, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841305/
https://ncbi.nlm.nih.gov/pubmed/19553539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900054
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