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Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase

Resistance to therapeutics such as trimethoprim-sulfamethoxazole has become an increasing problem in strains of methicillin-resistant S. aureus (MRSA). Clinically isolated trimethoprim-resistant strains reveal a double mutation, H30N/F98Y, in dihydrofolate reductase (DHFR). In order to develop novel...

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Detalhes bibliográficos
Main Authors: Frey, Kathleen M., Lombardo, Michael N., Wright, Dennis L., Anderson, Amy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841211/
https://ncbi.nlm.nih.gov/pubmed/20026215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2009.12.011
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