Widespread and tissue specific age-related DNA methylation changes in mice

Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may be a risk factor for human colon cancer. It is not known whether this age-related DNA methylation phenomenon is specific to...

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Hlavní autoři: Maegawa, Shinji, Hinkal, George, Kim, Hyun Soo, Shen, Lanlan, Zhang, Li, Zhang, Jiexin, Zhang, Nianxiang, Liang, Shoudan, Donehower, Lawrence A., Issa, Jean-Pierre J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2010
Témata:
Letter
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840983/
https://ncbi.nlm.nih.gov/pubmed/20107151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.096826.109
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