Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds

The dimerization and trimerization of the Dmt-Tic, Dmt-Aia and Dmt-Aba pharmacophores provided multiple ligands which were evaluated in vitro for opioid receptor binding and functional activity. Whereas the Tic- and Aba multimers proved to be dual and balanced δ/μ antagonists, as determined by the f...

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Autori principali: Ballet, Steven, Marczak, Ewa D., Feytens, Debby, Salvadori, Severo, Sasaki, Yusuke, Abell, Andrew D., Lazarus, Lawrence H., Balboni, Gianfranco, Tourwé, Dirk
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840614/
https://ncbi.nlm.nih.gov/pubmed/20137938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.055
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