Prototypic Opioid Peptidomimetics Based on the Dmt-Aba-Gly Scaffold

Peptidomometic analogues, H-Dmt-Tic-NH(2)-CH(2)-Ph or -Bid exhibit δ-opioid receptor activities. Substitution of Tic by the Aba-Gly scaffold coupled to the C-termini -CH(2)-Ph (1), -NH-Ph (2) and Gly*-Bid (3) shifted receptor affinity and selectivity to μ-opioid receptors (K(i)μ = 0.46, 1.48 and 19....

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Tourwé, Dirk, Salvadori, Severo, Bryant, Sharon D., Jinsmaa, Yunden, Lazarus, Lawrence H., Negri, Lucia, Giannini, Elisa, Lattanzi, Roberta, Balboni, Gianfranco
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2006
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2983084/
https://ncbi.nlm.nih.gov/pubmed/16789756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0603264
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