The Adaptor Molecule MyD88 Activates PI-3 Kinase Signaling in CD4(+) T Cells and Enables CpG Oligodeoxynucleotide-Mediated Costimulation

While T cells respond directly to toll-like receptor (TLR) agonists, TLR-signaling pathways in T cells are poorly characterized. Here we demonstrate in CD4(+) T cells that CpG DNA directly enhances proliferation, prevents anergy, and augments humoral responses to a T cell-dependent antigen by a Myel...

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Autori principali: Gelman, Andrew E., LaRosa, David F., Zhang, Jidong, Walsh, Patrick T., Choi, Yongwon, Sunyer, J. Oriol, Turka, Laurence A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840381/
https://ncbi.nlm.nih.gov/pubmed/17055754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2006.08.023
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