CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells

Toll-like receptor (TLR) ligands are notable for their ability to induce APC maturation, which in turn facilitates optimal T cell mediated immune responses. Toll-like receptor ligands, such as CpG DNA, can also modulate immune responses by blocking the suppressive effects of CD4+CD25+ regulatory T c...

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Bibliographic Details
Main Authors: LaRosa, David F., Gelman, Andrew E., Rahman, Adeeb H., Zhang, Jidong, Turka, Laurence A., Walsh, Patrick T.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1862558/
https://ncbi.nlm.nih.gov/pubmed/17270282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2006.12.007
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