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CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism
Toll-like receptor (TLR) ligands are known to activate antigen presenting cells (APCs), but direct T cell responsiveness to TLR ligands is controversial. Because of their clinical relevance, we performed in depth studies of the effects of the TLR9-associated ligands, oligodeoxynucleotides (ODNs), on...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169723/ https://ncbi.nlm.nih.gov/pubmed/21844387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003414 |
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