A broad-spectrum antiviral targeting entry of enveloped viruses

We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp contrast, the compound had no effect on the infection of nonenveloped viruses. I...

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Hauptverfasser: Wolf, Mike C., Freiberg, Alexander N., Zhang, Tinghu, Akyol-Ataman, Zeynep, Grock, Andrew, Hong, Patrick W., Li, Jianrong, Watson, Natalya F., Fang, Angela Q., Aguilar, Hector C., Porotto, Matteo, Honko, Anna N., Damoiseaux, Robert, Miller, John P., Woodson, Sara E., Chantasirivisal, Steven, Fontanes, Vanessa, Negrete, Oscar A., Krogstad, Paul, Dasgupta, Asim, Moscona, Anne, Hensley, Lisa E., Whelan, Sean P., Faull, Kym F., Holbrook, Michael R., Jung, Michael E., Lee, Benhur
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840368/
https://ncbi.nlm.nih.gov/pubmed/20133606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909587107
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