A broad-spectrum antiviral targeting entry of enveloped viruses

We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp contrast, the compound had no effect on the infection of nonenveloped viruses. I...

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Hlavní autoři: Wolf, Mike C., Freiberg, Alexander N., Zhang, Tinghu, Akyol-Ataman, Zeynep, Grock, Andrew, Hong, Patrick W., Li, Jianrong, Watson, Natalya F., Fang, Angela Q., Aguilar, Hector C., Porotto, Matteo, Honko, Anna N., Damoiseaux, Robert, Miller, John P., Woodson, Sara E., Chantasirivisal, Steven, Fontanes, Vanessa, Negrete, Oscar A., Krogstad, Paul, Dasgupta, Asim, Moscona, Anne, Hensley, Lisa E., Whelan, Sean P., Faull, Kym F., Holbrook, Michael R., Jung, Michael E., Lee, Benhur
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840368/
https://ncbi.nlm.nih.gov/pubmed/20133606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909587107
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