A broad-spectrum antiviral targeting entry of enveloped viruses

We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp contrast, the compound had no effect on the infection of nonenveloped viruses. I...

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Main Authors: Wolf, Mike C., Freiberg, Alexander N., Zhang, Tinghu, Akyol-Ataman, Zeynep, Grock, Andrew, Hong, Patrick W., Li, Jianrong, Watson, Natalya F., Fang, Angela Q., Aguilar, Hector C., Porotto, Matteo, Honko, Anna N., Damoiseaux, Robert, Miller, John P., Woodson, Sara E., Chantasirivisal, Steven, Fontanes, Vanessa, Negrete, Oscar A., Krogstad, Paul, Dasgupta, Asim, Moscona, Anne, Hensley, Lisa E., Whelan, Sean P., Faull, Kym F., Holbrook, Michael R., Jung, Michael E., Lee, Benhur
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840368/
https://ncbi.nlm.nih.gov/pubmed/20133606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909587107
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