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Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells

Tyrosine autophosphorylation of receptor tyrosine kinases plays a critical role in regulation of kinase activity and in recruitment and activation of intracellular signaling pathways. Autophosphorylation is mediated by a sequential and precisely ordered intermolecular (trans) reaction. In this repor...

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Autors principals: Bae, Jae Hyun, Boggon, Titus J., Tomé, Francisco, Mandiyan, Valsan, Lax, Irit, Schlessinger, Joseph
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840318/
https://ncbi.nlm.nih.gov/pubmed/20133753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914157107
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