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Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening

Fibroblast Growth Factors (FGFs) play important roles in embryonic development, angiogenesis, wound healing, and cell proliferation and differentiation. In search of inhibitors of FGFR1 kinase, 2.2 million compounds were docked into the ATP binding site of the protein. A co-crystal structure, which...

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Detalhes bibliográficos
Main Authors: Ravindranathan, Krishna P., Mandiyan, Valsan, Ekkati, Anil R., Bae, Jae H., Schlessinger, Joseph, Jorgensen, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842983/
https://ncbi.nlm.nih.gov/pubmed/20121196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901386e
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