Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy

Refractory temporal lobe epilepsy (TLE) is associated with a dysfunction of inhibitory signaling mediated by GABA(A) receptors. In particular, the use-dependent decrease (run-down) of the currents (I(GABA)) evoked by the repetitive activation of GABA(A) receptors is markedly enhanced in hippocampal...

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Autori principali: Mazzuferi, Manuela, Palma, Eleonora, Martinello, Katiuscia, Maiolino, Francesca, Roseti, Cristina, Fucile, Sergio, Fabene, Paolo F., Schio, Federica, Pellitteri, Michele, Sperk, Guenther, Miledi, Ricardo, Eusebi, Fabrizio, Simonato, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840298/
https://ncbi.nlm.nih.gov/pubmed/20133704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914710107
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