Strychnine activates neuronal α7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains

Recent work has shown that strychnine, the potent and selective antagonist of glycine receptors, is also an antagonist of nicotinic acetylcholine (AcCho) receptors including neuronal homomeric α7 receptors, and that mutating Leu-247 of the α7 nicotinic AcCho receptor-channel domain (L247Tα7; mut1) c...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Palma, Eleonora, Fucile, Sergio, Barabino, Benedetta, Miledi, Ricardo, Eusebi, Fabrizio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23963/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10557336/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.23.13421
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