Strychnine activates neuronal α7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains

Recent work has shown that strychnine, the potent and selective antagonist of glycine receptors, is also an antagonist of nicotinic acetylcholine (AcCho) receptors including neuronal homomeric α7 receptors, and that mutating Leu-247 of the α7 nicotinic AcCho receptor-channel domain (L247Tα7; mut1) c...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Palma, Eleonora, Fucile, Sergio, Barabino, Benedetta, Miledi, Ricardo, Eusebi, Fabrizio
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1999
Teme:	Biological Sciences
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23963/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10557336/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.23.13421
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