Strychnine activates neuronal α7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains

Recent work has shown that strychnine, the potent and selective antagonist of glycine receptors, is also an antagonist of nicotinic acetylcholine (AcCho) receptors including neuronal homomeric α7 receptors, and that mutating Leu-247 of the α7 nicotinic AcCho receptor-channel domain (L247Tα7; mut1) c...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Palma, Eleonora, Fucile, Sergio, Barabino, Benedetta, Miledi, Ricardo, Eusebi, Fabrizio
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1999
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23963/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10557336/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.23.13421
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